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. 2021 Sep 13;10:e68671. doi: 10.7554/eLife.68671

Table 4. Associations between quartile methylation level of identified CpGs and cardiometabolic traits, and the risk of coronary heart disease mediated through different cardiometabolic traits.

Table 4—source data 1. Association between quartile methylation level of identified CpGs and systolic blood pressure (mmHg).
Table 4—source data 2. Association between quartile methylation level of identified CpGs and diastolic blood pressure (mmHg).
Table 4—source data 3. Association between quartile methylation level of identified CpGs and total cholesterol (mmol/L).
Table 4—source data 4. Association between quartile methylation level of identified CpGs and cholesterol in low-density lipoprotein (mmol/L).
Table 4—source data 5. Association between quartile methylation level of identified CpGs and cholesterol in high-density lipoprotein (mmol/L).
Table 4—source data 6. Association between quartile methylation level of identified CpGs and random glucose (mmol/L).
Table 4—source data 7. Association between quartile methylation level of identified CpGs and triglyceride (mmol/L).


 Quartile 1 vs. 4 P for trend Mediation effect
Effect size(SE)* P Proportion mediated, % P
Systolic blood pressure†, mmHg




cg23398826 -6.410 (2.118) 0.003 <0.001 7.65 0.003
cg13311494 -6.580 (2.122) 0.002 0.020 15.61 0.031
Diastolic blood pressure†, mmHg




cg23398826 -3.574 (1.218) 0.003 <0.001 6.39 0.006
cg13311494 -3.650 (1.221) 0.003 0.029 12.38 0.045
Total cholesterol, mmol/L




cg26334131 0.197 (0.089) 0.026 0.003 -31.62 0.168
cg05740632 0.163 (0.089) 0.066 0.013 -3.21 0.126
cg21210537 0.175 (0.094) 0.064 0.027 -8.19 0.197
cg19583211 -0.064 (0.088) 0.466 0.047 2.73 0.270
Cholesterol in LDL, mmol/L




cg26334131 0.110 (0.063) 0.079 0.007 -32.14 0.135
cg20302171 0.107 (0.063) 0.09 0.029 -10.48 0.161
cg05740632 0.109 (0.063) 0.083 0.019 -3.38 0.110
cg19583211 -0.078 (0.062) 0.208 0.020 3.60 0.210
cg13311494 -0.117 (0.062) 0.06 0.027 3.70 0.208
cg21210537 0.126 (0.067) 0.059 0.044 -8.55 0.177
Cholesterol in HDL, mmol/L




cg15833447 0.037 (0.026) 0.154 0.013 -10.77 0.180
cg21210537 0.040 (0.027) 0.146 0.019 7.30 0.235
Random blood glucose‡, mmol/L




cg10400937 0.551 (0.231) 0.017 0.003 6.72 0.107
cg01545454 0.203 (0.234) 0.385 0.006 9.58 0.097
cg11754670 0.466 (0.236) 0.049 0.005 36.39 0.086
cg26334131 -0.517 (0.234) 0.028 0.018 32.70 0.109
cg07219103 0.578 (0.244) 0.018 0.032 6.17 0.135
cg20302171 -0.556 (0.234) 0.018 0.027 15.77 0.123
*

Effect sizes denoted the differences of metabolic traits between the top and bottom quartile methylation level. Details of other quartiles were reported in the Table 4—source data 1.

†

We added 15 and 10 mmHg to the measured systolic blood pressure and diastolic blood pressure respectively among participants who reported usage of blood pressure-lowering medications.

‡

Additionally adjusted for treatment of diabetes (yes or no) at baseline. Multivariable model was adjusted for: age, sex, education level, marital status, smoking, drinking, physical activity, dietary score, body mass index, fasting time, study area, and batch. The CpGs which were significantly associated with any metabolic risk factors were reported. Details of other CpGs were reported in the Supplementary tables. CpG = cytosine-phosphoguanine site; SE = standard error; LDL = low-density lipoprotein; HDL = high-density lipoprotein.