Table 1. Patient's characteristics.
| Variables | Case 1 | Case 2 | |
|---|---|---|---|
| Age (yr) | 50 | 63 | |
| Gender | Male | Male | |
| Education (yr) | 14 | 9 | |
| Comorbidity | Arthritis for 4 years | None | |
| APOE genotype | E3/3 | E3/4 | |
| Symptom duration (mon) | 2–3 | 3–4 | |
| Neuropsychological test results (SNSB II) | |||
| K-MMSE | 28 | 26 | |
| CDR (SOB) | 0.5 (2.0) | 0.5 (3.5) | |
| K-IADL | 0.2 | 0.4 | |
| Geriatric depression scale | 8/15 | 14/15 | |
| Digit span forward (%ile) | 41.99 | 51.59 | |
| K-BNT (%ile) | 0.01 | 54.87 | |
| RCFT (%ile) | 0.01 | 0.28 | |
| SVLT, immediate recall (%ile) | 1.75 | 0.10 | |
| SVLT, delayed recall (%ile) | 0.31 | 1.85 | |
| SVLT, recognition (%ile) | 25.26 | 28.39 | |
| RCFT, immediate recall (%ile) | 0.17 | 2.07 | |
| RCFT, delayed recall (%ile) | 0.06 | 3.55 | |
| RCFT, recognition (%ile) | 32.70 | 13.79 | |
| COWAT, phonemic (%ile) | 8.91 | 11.39 | |
| Stroop, color reading (%ile) | 4.87 | 0.02 | |
| Brain MRI findings | |||
| Lacune (No.) | 0 | 0 | |
| White matter hyperintensities | P1/D1, minimal | P1/D1, minimal | |
| Microbleed (No.) | 0 | 0 | |
| Hippocampal atrophy, grade | G2/2 | G1/1 | |
| Syphilis work ups | |||
| Serum | RPR, quan: reactive (1:128) | RPR, quan: reactive (1:128) | |
| TPHA: reactive | TPHA: reactive | ||
| FTA-ABS, IgM: negative | FTA-ABS, IgM: positive | ||
| FTA-ABS, IgG: positive | FTA-ABS, IgG: positive | ||
| HIV Ag/Ab: negative | HIV Ag/Ab: negative | ||
| CSF | WBC: 71 (Lymphocytes 83%), RBC: 0 | WBC: 83 (Lymphocytes 95.2%), RBC: 20 | |
| Protein: 65.8 mg/dL | Protein: 74.6 mg/dL | ||
| Glucose: 58 mg/dL | Glucose: 43 mg/dL | ||
| CSF syphilis markers | RPR, quan: reactive (1:16) | RPR, quan: reactive (1:16) | |
| TPHA: reactive | TPHA: reactive | ||
| FTA-ABS, IgM: weakly positive | FTA-ABS, IgM: negative | ||
| FTA-ABS, IgG: positive | FTA-ABS, IgG: positive | ||
APOE: apolipoprotein, K-MMSE: Korean version of the Mini-Mental State Examination, CDR: clinical dementia rating, SOB: sum of boxes, K-IADL: Korean version of instrumental activities of daily living, K-BNT: Korean version of Boston naming test, RCFT: Rey complex figure test, SVLT: Seoul verbal learning test, COWAT: Controlled Oral Word Association Test, MRI: magnetic resonance imaging, P: periventricular, D: deep white matter, RPR: rapid plasma reagin, TPHA: Treponema pallidum hemagglutination assay, FTA-ABS: fluorescent treponemal antibody absorption test, HIV: human immunodeficiency virus, CSF: cerebrospinal fluid, WBC: white blood cell, RBC: red blood cell.