Table 1.
Overview of circRNAs identified by RNA-seq and microarray in PCa
| Sample | Special treatment | Detection method | GEO database | Data source | Total circRNA | Number of circRNA differently expressed (fold change ≥2) | circRNAs validated by qRT-PCR | Reference | Year |
|---|---|---|---|---|---|---|---|---|---|
| One pair PCa and PCN tissues | – | circRNA microarray | GSE155792 | circRNA microarray | 170,340 | – | five | Deng et al.63 | 2020 |
| Three pair PCa and PCN tissues | RNase R | circRNA microarray | – | circRNA microarray | – | 15 (three upregulated, 12 downregulated) | one | Li et al.64 | 2020 |
| Four pair PCa and PCN tissues | RNase R | ceRNA microarray | – | ceRNA microarray | 88,371 | 1,021 (117 upregulated, 904 downregulated) | three | Xia et al.59 | 2018 |
| Five pairs HGT and LGT | – | circRNA microarray | – | circRNA microarray | – | 2,238(1,238 upregulated, 1,000 downregulated) | five | Yang et al.65 | 2019 |
| Five pair PCa and PCN tissues | – | circRNA microarray | – | circRNA microarray | 12,532 | 95 (71 upregulated, 24 downregulated) | three | Song et al.66 | 2019 |
| Five pair PCa and PCN tissues | RNase R | circRNA microarray | – | circRNA microarray | 7,385 | 988 (436 upregulated, 552 downregulated) | five | Shang et al.67 | 2020 |
| Five pair PCa and PCN tissues | – | circRNA microarray | – | circRNA microarray | 88,750 | 749 (261 upregulated, 487 downregulated) | – | Ge et al.58 | 2020 |
| Six pair PCa and PCN tissues | – | circRNA microarray | – | circRNA microarray | 9,599 | 177 (43 upregulated, 134 downregulated) | six | Rochow et al.57 | 2020 |
| Blood samples from the six patients and six healthy persons | RNase R | circRNA microarray | – | circRNA microarray | – | 109 (69 upregulated, 42 downregulated) | eight | Li et al.68 | 2020 |
| H-k LNCaP cells and normal LNCaP cells | RNase R | Sanger sequencing | GSE72844 | RNA-seq | 4,389 | 139 upregulated and 93 downregulated | six | Fei et al.28 | 2017 |
| LNCaP cell line | RNase R | circRNA microarray | GSE118959 | circRNA microarray | 13,617 | 930 (278 upregulated, 588 downregulated) | 10 | Greene et al.69 | 2019 |
| LNCaP-miR-145 cells and LNCaP-NC | – | circRNA microarray | – | circRNA microarray | 10,743 | 267 upregulated, 149 upregulated | five | He et al.70 | 2018 |
| PC-3M IE8 cells | RNase R | circRNA microarray | – | bioinformatics analysis | 4,788 | 827 upregulated and 1,279 downregulated | four | Yan et al.60 | 2020 |
| RWPE-1, 22RV1 and PC3 cell lines | RNase R | RNA-seq | – | RNA-seq and bioinformatics analysis | 9,545 | – | 20 | Zhang et al.61 | 2018 |
HGT, high-grade (Gleason > 8) PCa tissues; LGT low-grade (Gleason < 6) PCa tissues; PCN, PCa tissues paired adjacent normal prostate tissues; H-k, HNRNPL-knockdown; NC, normal control.
HGT and LGT taken from the two different areas within the same PCa sample.