Table 2.
Dysregulated circRNAs in PCa
| Name | CircBase ID | Expression change | Target | Gene | Function | Types of PCa tissues and PCa cell lines | Reference | Year |
|---|---|---|---|---|---|---|---|---|
| circSMARCA5 | hsa_circ_0001445 | up | – | – | promoted cell proliferation and inhibited cell apoptosis | 21 pairs of PCa tissues and adjacent normal tissues; LNCaP, LNCaP-AI, 22RV1, DU145, PC-3, and WPMY-1 cell lines | Kong et al.72 | 2017 |
| circRNA-MYLK | hsa_circ_0141940 | up | miR-29a | – | promoted proliferation, invasion, and migration | 17 pairs of PCa tissues and adjacent normal tissues; DU145, LNCaP, PC-3, PC-3MIE8, and WPMY-1 cell lines | Dai et al.73 | 2018 |
| circ-102004 | – | up | – | – | promoted cell proliferation, migration and invasion; decreased cell apoptosis | 16 PCa samples and six normal prostate tissues; PC3 and 22RV1 cell lines | Si-Tu et al.74 | 2018 |
| circCSNK1G3 | hsa_circ_0001522 | up | miR-181b/day | – | promoted cell proliferation | LNCaP, 22Rv1, PC-3, and V16A cell lines | Chen et al.32 | 2019 |
| circABCC4 | hsa_circ_0030586 | up | miR-1182 | FOXP4 | promoted cell proliferation, migration, and invasion | 47 pairs of PCa tissues and adjacent normal tissues; PC3 and DU145 cells | Huang et al.75 | 2019 |
| circ0005276 | hsa_circ_0005276 | up | – | – | promoted cell proliferation and migration | 90 pairs of PCa tissues and adjacent normal tissues; DU145, LNCaP, PC-3, VCaP, and RWPE-1 cell lines | Feng et al.76 | 2019 |
| circAGO2 | hsa_circ_0135889 | up | – | – | promoted proliferation, invasion, and metastasis | PC-3 cell line | Cheng et al.77 | 2019 |
| circHIPK3 | hsa_circ_0000284 | up | miR-193a-3p | MCL1 | promoted cell proliferation, migration, and invasion | 26 pairs of PCa tissues and adjacent normal tissues; LNCaP, PC3, DU145, 22Rv1, and RWPE-1 cell lines | Chen et al.78 | 2019 |
| circHIPK3 | hsa_circ_0,000284 | up | miR-338-3p | ADAM17 | promoted cell proliferation and invasion | 60 pairs of PCa tissues and adjacent normal tissues; 22RV1, PC-3, DU145, LNCaP, and RWPE-1 cell lines | Cai et al.79 | 2019 |
| circZNF609 | hsa_circ_0000615 | up | miR-186-5p | – | promoted cell proliferation and metastasis | 25 pairs of PCa tissues and adjacent normal tissues; PC-3 and LNCaP cell lines | Jin et al.80 | 2019 |
| circRNA-51217 | – | up | miR-646 | TGFβ1 | promoted cell invasion | C4-2, PC3, DU145, LNCaP, and HEK293T cell lines | Xu et al.81 | 2020 |
| circ_0044516 | hsa_circ_0044516 | up | miR-29a-5p | – | promoted cell proliferation and metastasis | blood samples from the six patients and six healthy persons; PC3, 2B4, LNcap, and 5637 cell lines | Li et al.68 | 2020 |
| hsa_circ_0000735 | hsa_circ_0000735 | up | miR-7 | – | promoted cell viability, migration, invasion; inhibited cell apoptosis and cell resistance to docetaxel | 50 pairs of PCa tissues and adjacent normal tissues; PC3, DU145, PC-3/DTX, DU145/DTX, and RWPE-1 cell lines | Gao et al.82 | 2020 |
| circ-ZNF609 | hsa_circ_0000615 | up | miR-501-3p | HK2 | promoted cell proliferation, migration and glycolysis; inhibited cell apoptosis | 30 pairs of PCa tissues and adjacent normal tissues; 22RV1, VCaP, DU145, LNCap, and RWPE-1 cell lines | Du et al.83 | 2020 |
| circ_CCNB2 | hsa_circ_0035483 | up | miR-30b-5p | KIF18A | promoted cell proliferation, migration and autophagy; inhibited apoptosis | 25 pairs of PCa tissues and adjacent normal tissues; DU145, LNCaP, DU145/IR, and LNCaP/IR cell lines | Cai et al.84 | 2020 |
| circMBOAT2 | hsa_circ_0007334 | up | miR-1271-5p | mTOR | promoted cell proliferation, migration, and invasion | 50 pairs of PCa tissues and adjacent normal tissues; LNCaP, VCaP, PC3, DU145, C4-2B, and RWPE-1 cell lines | Shi et al.85 | 2020 |
| circFOXO3 | hsa_circ_0006404 | up | miR-29a-3p | SLC25A15 | promoted cell proliferation and inhibited cell apoptosis | 53 pairs of PCa tissues and adjacent normal tissues; blood samples from the 26 patients and 19 healthy persons; LNCaP, 22Rv1, DU145, PC-3, and WPMY-1 cell lines | Kong et al.86 | 2020 |
| circZMIZ1 | hsa_circ_0005844 | up | – | – | promoted cell proliferation | blood samples from the 14 patients and 14 healthy persons; DU145, C4-2, LNCaP, 22RV1, and RWPE-1 cell lines | Jiang et al.87 | 2020 |
| circ_0057553 | hsa_circ_0057553 | up | miR-515-5p | YES1 | promoted cell viability, migration, invasion, and glycolysis; inhibited cell apoptosis | 37 pairs of PCa tissues and adjacent normal tissues; 22RV1, PC3, DU145, LNCap, and RWPE-1 cell lines | Zhang et al.88 | 2020 |
| circ_0088233 | hsa_circ_0088233 | up | miR-185-3p | E2F1 and WNT2B | promoted cell proliferation, migration, invasion, and inhibited apoptosis | 46 pairs of PCa tissues and adjacent normal tissues; LNCaP, PC3, DU145, 22Rv1, and RWPE-1 cell lines | Deng et al.63 | 2020 |
| circ-0016068 | hsa_circ_0016068 | up | miR-330-3p | BMI-1 | promoted cell proliferation, migration, and invasion | 42 pairs of PCa tissues and adjacent normal tissues; VCaP, PC3, DU145, 22RV1, and RWPE-1 cell lines | Li et al.64 | 2020 |
| circ_SLC19A1 | hsa_circ_0062019 | up | miR-497 | SEPT2 | promotes cell growth and invasion | PC3, 22Rv1, DU145, LNCaP, and WPMY-1 cell lines | Zheng et al.89 | 2020 |
| circFMN2 | hsa_circ_0005100 | up | miR-1238 | LHX2 | promoted cell proliferation, migration, and invasion; inhibited apoptosis and EMT | 90 pairs of PCa tissues and adjacent normal tissues; blood samples from the 30 patients and 30 healthy persons; VCaP, PC3, DU145, LNCaP, and RWPE-1 cell lines | Shang et al.67 | 2020 |
| circHIPK3 | hsa_circ_0000284 | up | miR-338-3p | Cdc25B | promoted cell proliferation and inhibited apoptosis | 45 PCa samples and 25 normal prostate tissues; LNCaP, DU145, PC3, 22RV1, and RWPE-1 cell lines | Liu et al.90 | 2020 |
| circSMARCA5 | hsa_circ_0071043 | up | miR-432 | PDCD10 | accelerated the proliferation, metastasis, and glycolysis of cells | 30 pairs of PCa tissues and adjacent normal tissues; DU145, 22RV1, and RWPE-1 cell lines | Dong et al.91 | 2020 |
| circSLC19A1 | hsa_circ_0062019 | up | miR-326 | MAPK1 | promoted the proliferation, migration, and invasion of PCa cells | 48 pairs of PCa tissues and adjacent normal tissues; DU145, PC3, LNCaP, 22RV1, and RWPE-1 cell lines | Huang92 | 2020 |
| circ_0062020 | hsa_circ_0062020 | up | miR-615-5p | – | promoted cell proliferation, migration, and invasion; inhibited apoptosis and radiosensitivity | 30 radiosensitive PCa samples, 30 radioresistant PCa samples and 30 normal prostate tissues; DU145, LNCaP, and WPMY-1cell lines | Li et al.93 | 2020 |
| circRNA17 | hsa_circ_0001427 | down | miR-181c-5p | ARv7 | inhibited cell enzalutamide resistance and invasion | 26 PCa samples and 13 normal prostate tissues; C4–2, CWR22Rv1, and 293T cell lines | Wu et al.94 | 2019 |
| circSMAD2 | hsa_circ_0047603 | down | miR-9 | STAT and MEK/ERK pathways | inhibited cell proliferation and migration; blocked EMT process | 20 pairs of PCa tissues and adjacent normal tissues; LNCaP and PC3 cell lines | Han et al.95 | 2019 |
| circ_ITCH | hsa_circ_0001141 | down | miR-197 | – | inhibited cell proliferation and promoted cell apoptosis | DU 145, 22RV1, VCaP, PC-3, and RWPE-1 cell lines | Yuan et al.96 | 2019 |
| hsa_circ_0001206 | hsa_circ_0001206 | down | miR-1285-5p | Smad4 | inhibited cell proliferation, migration, and invasion | 50 pairs of PCa tissues and adjacent normal tissues; DU145, PC-3, LNCaP, and RWPE-1 cell lines | Song et al.66 | 2019 |
| circ_ITCH | hsa_circ_0001141 | down | miR-17-5p | HOXB13 | suppressed cell growth, invasion and metastasis; induced cell apoptosis | 52 pairs of PCa tissues and adjacent normal tissues; C4-2, LNCaP, DU145, 22Rv1, PC-3, VcaP, and RWPE-1 cell lines | Wang et al.97 | 2019 |
| circUCK2 | hsa_circ_001,357 | down | miR-767-5p | TET1 | inhibited cell proliferation and invasion | C4-2 cell line | Xiang et al.98 | 2019 |
| hsa_circ_0004870 | hsa_circ_0004870 | down | miR-145 | RBM39 | – | LNCaP cell line | Greene et al.69 | 2019 |
| circAMOTL1L | hsa_circ_000,350 | down | miR-193a-5p | PCDHA8 | inhibited cell migration and invasion | 62 PCa samples, and 35 normal prostate tissues; Du145, LNCaP, PC3, and RWPE-1 cell lines | Yang et al.65 | 2019 |
| circDDX17 | hsa_circ_0063308 | down | miR-346 | LHPP | inhibited cell proliferation, invasion, and EMT | 20 pairs of PCa tissues and adjacent normal tissues; 22Rv1 and PC-3 cell lines | Lin et al.99 | 2020 |
| circCRKL | hsa_circ_0001206 | down | miR-141 | KLF5 | repressed cell cycle, migration, and invasion, and boosted apoptosis | 45 pairs of PCa tissues and adjacent normal tissues; LNCaP, DU145, C4-2, 22RV1, and RWPE-1 cell lines | Nan et al.100 | 2020 |
| hsa_circ_0007494 | hsa_circ_0007494 | down | miR-616 | PTEN | inhibited cell proliferation, migration, and invasion | 49 pairs of PCa tissues and adjacent normal tissues; C4-2, PC3, 22Rv1, DU145, LNCaP, and RWPE-1 cell lines | Zhang et al.101 | 2020 |
| circ_KATNAL1 | hsa_circ_0008068 | down | miR-145-3p | WISP1 | inhibited cell proliferation and invasion; promoted cell apoptosis | 22Rv1, DU145, LNCaP, PC3, and WPMY-1 cell lines | Zheng et al.102 | 2020 |
| cir-ITCH | hsa_circ_0001141 | down | miR-17 | Wnt/β-catenin and PI3K/AKT/mTOR pathways | inhibited cell proliferation, migration, and invasion | 10 pairs of PCa tissues and adjacent normal tissues; LNCaP, PC-3, and RWPE-1 cell lines | Li et al.103 | 2020 |
| circ-MTO1 | hsa_circ_0076979 | down | miR-17-5p | – | inhibited cell proliferation and invasion | 298 pairs of PCa tissues and adjacent normal tissues; DU145, PC-3, VCaP, and RWPE-1 cell lines | Hu et al.104 | 2020 |
| circ-LARP4 | hsa_circ_0026224 | down | – | FOXO3A | inhibited cell migration and invasion | 55 pairs of PCa tissues and adjacent normal tissues; 22RV1, DU145, LNCap, and P69 cell lines | Weng et al.105 | 2020 |
| circFoxo3 | hsa_circ_0006404 | down | – | FOXO3 | inhibited cell survival, migration, invasion, and chemoresistance to docetaxel | 22 low-grade PCa samples, 24 high-grade PCa samples, and 18 normal prostate tissues; VCaP, LNCaP, Du145, PC3, and PWPE1 cell lines | Shen et al.106 | 2020 |