Table 1.
Deceased donors with VITT
| Greenhall et al8 | Centonze et al10 | Loupy et al9 | NHS Blood and Transplantation INF1569/3.17 | Present Case | |
|---|---|---|---|---|---|
| No of donors consented | 13 | 1 | 5 | 18 | 1 |
| Median age in years | 34 | 32 | 66 | NA | 18 |
| Actual donations from deceased donors (n) | 10 | 1 | 3 | NA | 1 |
| Female n(%) | 11 (85%) | 1 (100% | NA | 1 (100%) | |
| DBD | 13 (100%) | 1 (100%) | 3 (60%) | NA | 1 (100%) |
| Time of vaccination to presentation to (days) | 10 | 11 | 13 | NA | 9 |
| Vaccine administered | ChAdOx1 nCoV -19 1st dose | ChAdOx1 nCov-19 | ChAdOx1 n-CoV-19 | NA | ChAdOx1 n-CoV-19 1st dose |
| CVST n(%) | 13 (100%) | 1 (100%) | 4 (80%) | NA | 1 (100%) |
| Intracranial hemorrhage n(%) | 7 (54%) | Nil | 5 (100%) | NA | 1 (100%) |
| Extracranial thrombosis n(%) | 6 (46%) | Nil | 5 (100%) | NA | Nil |
| Splanchnic n(%) | 3 (23%) 1: portal; 1: splenic; 1: mesenteric vein |
1 (100%) hepatic vein thrombosis |
4 (80%) | NA | Nil |
| Pulmonary n(%) | 2 (15%) | Nil | 2 (40%) | NA | Nil |
| Other | 1 (7%) Aorta | Nil | 1 (20%) adrenal vein thrombosis | NA | Nil |
| D- dimer ng/ml | 41,000 | 12,080 | >20,000 | NA | 14,360 |
| Platelet count mm3 | 26,000 | 35,000 | 25,000 | NA | 50,000 |
| Anti-PF4 antibodies n(%) | 13 (100%) | Nil | 4 (80%) | NA | Nil |
DBD, donation after brain death; CVST, cerebral venous sinus thrombosis; NA, not available; VITT, vaccine-induced thrombotic thrombocytopenia.