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. 2021 Nov 12;145:112420. doi: 10.1016/j.biopha.2021.112420

Table 3.

The top 10 KEGG pathways for the 561 genes that mediate the pathway cross-talks.

Category Term Count % q-value
KEGG_PATHWAY Cytokine-cytokine receptor interaction 197 35.1 8.40E-181
KEGG_PATHWAY Jak-STAT signaling pathway 127 22.6 8.50E-121
KEGG_PATHWAY Chemokine signaling pathway 130 23.2 1.60E-100
KEGG_PATHWAY Toll-like receptor signaling pathway 92 16.4 5.00E-85
KEGG_PATHWAY TNF signaling pathway 91 16.2 1.80E-82
KEGG_PATHWAY Influenza A 111 19.8 2.20E-78
KEGG_PATHWAY NF-kappa B signaling pathway 80 14.3 4.30E-78
KEGG_PATHWAY Hepatitis B 97 17.3 6.60E-71
KEGG_PATHWAY T cell receptor signaling pathway 81 14.4 8.90E-70
KEGG_PATHWAY MAPK signaling pathway 124 22.1 1.10E-69

Table presents that the Cytokine-cytokine receptor interaction pathway significantly shares the most components between the pathways and can be one of the important pathways with critical roles in the SARS-CoV-2 infection.