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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Toxicology. 2021 Sep 17;463:152954. doi: 10.1016/j.tox.2021.152954

Figure 2.

Figure 2.

Comparison of intrinsic hepatic clearance of drugs across systems with in vivo clinical estimates. For each drug, clearance calculated from in vivo data (“Clinical”: triangles) is compared to that derived from in vitro hepatocyte suspension (“httk”: diamonds), monolayer culture (“2D”: circles) or perfusate through LAMPS chips (“3D”: squares) seeded with primary hepatocytes (“Primary”: filled symbols) or iCell hepatocytes 2.0 (“iPSC”: open symbols). For Primary/iPSC 2D/3D, only data at 24 hr (1st available time point) is used, as both in vivo and in vitro hepatocyte suspension data were collected at <24 hr.