. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Optom Vis Sci. 2021 Nov 1;98(11):1231–1238. doi: 10.1097/OPX.0000000000001802

Table 2.

Tear Film and Conjunctival Damage Associated Molecular Patterns (DAMPs) Levels in Normal and Dry Eye (DED) Subjects.

DAMP	Normal	DED	P-value
Tear film HMGB1 (ng/ml)	0.5 ± 0.3	9.5 ± 5.5	.03
Conj. HMGB1 (ng/ml)	121.7 ± 19.9	103.5 ± 16.6	.54
Tear film HSP-27 (MFI)	24056.0 ± 7029.0	47922.0 ± 17612.0	.22
Conj. HSP-27 (MFI)	56807.0 ± 8138.0	43204.0 ± 7429.0	.28
Tear film HSP-60 (MFI)	390.0 ± 91.2	391.4 ± 102.8	.99
Conj. HSP-60 (MFI)	9793.0 ± 977.9	9146.0 ± 1281	.62
Tear film HSP-70 (MFI)	561.3 ± 65.4	567.6 ± 139.9	.97
Conj. HSP-70 (MFI)	8225.0 ± 1059.0	6217.0 ± 1276.0	.22
Tear film HSP-90α (MFI)	13533.0 ± 3320	17816 ± 6450	.63
Conj. HSP-90α (MFI)	11600.0 ± 1611	9522.0 ± 1599.0	.38

Tear film and conjunctival impression cytology samples were analyzed to quantitate high-mobility group box 1 (HMGB1, ng/ml) and determine the medium fluorescence intensity (MFI) for heat shock protein (HSP)-27,−60. −70, and −90α.