Table 1:
Baseline Characteristics by Site-Level
| Outcome | COMB-R (N=6) |
ESC (N=7) |
P-value |
|---|---|---|---|
|
| |||
| Mean (s.d.) | Mean (s.d.) | ||
| % Male | 44.9 (24.4) | 44.6 (24.5) | 0.98 |
| Mean age (yrs) at entry | 21.5 (0.6) | 21.3 (1.8) | 0.74 |
| % Younger (12-18 yrs) | 17.1 (11.0) | 25.8 (28.3) | 0.50 |
| % Black | 65.1 (40.0) | 57.0 (32.6) | 0.69 |
| % with perinatal transmission | 49.1 (26.3) | 56.2 (22.1) | 0.61 |
| Mean QIDS-C | 16.6 (1.4) | 15.1 (2.0) | 0.15 |
| Mean ordinal QIDS-C | 3.7 (0.4) | 3.5 (0.3) | 0.25 |
| % with severe QIDS-C | 53.8 (21.9) | 42.6 (32.3) | 0.49 |
| Mean QIDS-SR | 16.2 (1.3) | 14.5 (3.2) | 0.26 |
| Mean ordinal QIDS-SR | 3.6 (0.3) | 3.3 (0.8) | 0.35 |
| % with severe QIDS-SR | 55.2 (16.5) | 39.3 (32.0) | 0.30 |
| Mean log10 RNA/ml | 2.2 (0.7) | 2.1 (0.3) | 0.82 |
| % with viral suppression (< 40 copies/ml) | 59.1 (27.3) | 56.2 (10.0) | 0.81 |
| Mean CD4 count/uL | 679.2 (150.7) | 704.7 (203.8) | 0.81 |
| % with stage 3 CD4 count (<200 cells/uL) | 9.8 (11.4) | 7.9 (9.9) | 0.76 |
| % with stage 3 nadir CD4 count | 28.3 (23.1) | 25.7 (21.1) | 0.83 |
| % with stage 3 CDC class | 20.3 (29.1) | 22.0 (21.5) | 0.91 |
| % on ARVs | 93.2 (6.7) | 92.0 (18.7) | 0.88 |
| % on integrase inhibitors | 73.8 (15.7) | 66.6 (32.1) | 0.63 |
| % on psychiatric medications | 28.0 (13.2) | 21.4 (19.0) | 0.49 |
| % on 2 or more psychiatric medications | 30.0 (20.0) | 44.8 (42.2) | 0.45 |
| % on anti-depressant medications | 25.2 (9.8) | 21.4 (19.0) | 0.67 |
| % on SSRI anti-depressant medications | 20.3 (10.5) | 15.8 (16.8) | 0.58 |
Note:
indicates p-value < 0.05, t-test with equal or unequal variances as appropriate based on F-test results
Note: For analysis of dichotomous variables, entries are means (s.d.) of site-specific percentages
Note: Quick Inventory for Depression Symptomatology Clinician Report (QIDS-C) and Self-Report (QIDS-SR) is scored from 0-27 with a higher score indicating greater symptom severity: 0-5 Not depressed, 6-10 Mild, 11-15 Moderate. 16-20 Severe, 21+ Very Severe
Note: Mean ordinal QIDS-C and QIDS-SR measures are ranked from 1-5 (none to very severe) and analyzed as a continuous measure
Note: Stage 3 nadir CD4 is computed across age ranges where Stage 3 was <750 cells (at < 1 year old), <500 cells at 1-5 yrs and < 200 cells at 6+ years
Note: Denominator for percent of participants on 2 or more psychiatric medications is the number on any psychiatric medication
Note: Denominator for percent of participants on INSTIs is the number on any ARV