Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Enzyme kinetics studies of (A) DV2pro and (B) ZVpro with inhibitor 66 at the increasing concentrations of the substrate from 0.5 to 100 μM (~0.05–11×Km for DV2pro and 0.03× to 1×Km for ZVpro). The IC50 values against DV2pro do not linearly increase according to the Cheng-Prusoff equation (IC50 = Ki + Ki/Km×[S]), suggesting compound 66 is not a competitive inhibitor of DV2pro and more likely adopts a non-competitive mode of inhibition.
