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. Author manuscript; available in PMC: 2022 Dec 5.
Published in final edited form as: Eur J Med Chem. 2021 Aug 14;225:113767. doi: 10.1016/j.ejmech.2021.113767

Table 7.

Inhibitory activity IC50 (μM) against Flavivirus proteases ZVpro, DV2pro and WVpro.a

ZVpro DV2pro WVpro
66 0.32 1.6 5.7
67 0.37 3.1 3.7
72 0.45 9.2 8.6
64 0.99 10.3 3.5
30 1.0 10.0 10.5
50 1.0 10.6 20.1
8 1.3 15.0 21.8
56 1.6 6.5 6.6
26 3.1 49.7 32.0
51 3.2 10.7 16.0
7 5.0 30.4 35.1
32 5.7 48.3 42.0
40 11.4 40.2 31.0
24 21.8 12.0 50.5
45 40.2 >50 >50
22 48.9 >50 >50
a

Standard errors of all IC50 values are less than 30%.