Fig. 5.

Pathways predicted to be affected in SERT KO vs. WT placenta. Functional enrichment analyses with the WEB-based Gene SeT AnaLysis Toolkit (WebGestalt) [41] and GO molecular function terms was performed based on DE genes to determine which pathways might be affected in SERT KO relative to WT placenta. As shown in this Fig., many of the pathways involve nutrient, enzyme, hormone binding activity, including for vitamins, lipids, carbohydrates, and proteins. Those categories surrounded by a dark blue box are significant based on a false discovery rate (FDR) ≤ 0.05, whereas categories surrounded by a light blue box are significant based on a p value ≤ 0.05. Connecting lines indicate inter-relationships between categories.