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Selected kinases inhibition of compounds 5e and 5g.
| Kinase | 5e IC50 (μM) | 5g IC50 (μM) |
|---|---|---|
| FLT3 | 0.053 ± 0.0091 | 0.31 ± 0.012 |
| NEK2 | >20 | >20 |
| RET | 6.83 ± 1.78 | 5.43 ± 0.02 |
| EGFR | >20 | >20 |
| CSF-1R | 8.56 ± 1.70 | 2.84 ± 0.026 |
| Aurora A | 1.30 ± 0.30 | 0.97 ± 0.098 |
| NIK | >10 | >10 |
