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. Author manuscript; available in PMC: 2022 Jun 5.

Published in final edited form as: Eur J Med Chem. 2021 Aug 17;225:113776. doi: 10.1016/j.ejmech.2021.113776

Table 5.

Anti-proliferative activities of selected compounds on MOLM14 cells.

	MOLM14-FLT3ITD GI₅₀(μM)	MOLM14-FLT3ITD^D835Y GI₅₀(μM)	MOLM14-FLT3ITD^F691L GI₅₀(μM)
5a	0.61 ± 0.088	1.68 ± 0.17	3.32 ± 021
5b	0.67 ± 0.079	1.57 ± 0.26	2.75 ± 0.49
5e	0.16 ± 0.029	1.50 ± 0.16	1.29 ± 0.22
5f	0.61 ± 0.060	10.24 ± 1.62	8.89 ± 0.87
5h	0.77 ± 0.068	3.24 ± 0.30	3.03 ± 0.52
5i	0.65 ± 0.11	1.56 ± 0.18	2.91 ± 0.41
5k	0.65 ± 0.060	0.55 ± 0.046	1.35 ± 0.21
5l	0.71 ± 0.084	3.11 ± 0.40	1.58 ± 0.11
5n	0.60 ± 0.083	1.73 ± 0.32	1.40 ± 0.11
5o	0.52 ± 0.062	0.53 ± 0.022	0.57 ± 0.058
5p	0.67 ± 0.054	1.42 ± 0.20	1.23 ± 0.24
5q	0.65 ± 0.056	1.15 ± 0.18	0.95 ± 0.18
Quizartinib	0.00015 ± 0.000015	0.012 ± 0.0026	0.027 ± 0.0035