Table 2. Summary of results of the ‘1000 mosaic embryo transfer’ study.
Columns indicate the measured clinical outcomes, and rows indicate the (sub-) category of result obtained with PGT-A. Low <50%; High ≥50%; Complex = more than 2 aberrant chromosomes.
| Implantation per Embryo Transfer | Ongoing Pregnancy/Birth per Embryo Transfer | Spontaneous Abortion per Implanted Embryo | P value | |
|---|---|---|---|---|
| Euploid (n=5561) | 57.2% | 52.3% | 8.6% | |
| Mosaic All (n=1000) | 46.5% | 37.0% | 20.4% | <0.0001 |
| Mosaic Whole Chromosome (n=517) | 41.8% | 31.3% | 25.0% | <0.0001 |
| Mosaic No Selection (n=467) | 44.1% | 35.3% | 20.4% | <0.0001 |
| Mosaic No Knowledge (n=164) | 55.5% | 37.2% | 33.0% | <0.0001 |
| Mosaic Low Segmental (n=385) | 50.9% | 43.9% | 13.8% | <0.0001 |
| Mosaic High Segmental (n=94) | 52.1% | 41.5% | 20.3% | |
| Mosaic Low One Chromosome (n=190) | 48.9% | 39.5% | 19.2% | |
| Mosaic Low Two Chromosome (n=93) | 45.2% | 39.8% | 11.9% | |
| Mosaic Low Complex (n=88) | 34.1% | 25.0% | 26.7% | |
| Mosaic High One Chromosome (n=67) | 32.8% | 22.4% | 31.7% | |
| Mosaic High Two Chromosome (n=30) | 33.3% | 20.0% | 40.0% | |
| Mosaic High Complex (n=38) | 23.7% | 13.2% | 44.0% |
Compared to the ‘Euploid’ group, the following mosaic groups had significantly lower likelihood of achieving ongoing pregnancy/birth per embryo transfer: ‘Mosaic All’, ‘Mosaic Whole Chromosome’, ‘Mosaic No Selection’, and ‘Mosaic No Knowledge’ (Chisquare, P<0.0001).
The indicated order of mosaic sub-groups is statistically significant (Cochran-Armitage test for trend, P<0.0001).
For each clinical outcome, the colored shading indicates the relative success rates of each (sub-) category, from best (white) to worst (red).