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. 2021 Oct 29;12:750110. doi: 10.3389/fgene.2021.750110

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Copyright © 2021 Smetana, Vallova, Wayhelova, Hladilkova, Filkova, Horinova, Broz, Mikulasova, Gaillyova and Kuglík.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FISH evaluations of the delXq22.3 region. (A) Metaphase chromosomes from the mother (III-4) showed FISH signal for the Xq22.3 region obtained using probe RP1-31B8 (green) on only one X chromosome. Probe for X chromosome centromeric region (RP13-34C21—red) showed FISH signals in both chromosomes. (B) Metaphase chromosomes from the proband (IV-I) showed no FISH signal for the Xq22.3 region and only one signal for the X chromosome centromeric region.