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. 2021 Oct 29;15:701317. doi: 10.3389/fnins.2021.701317

FIGURE 2.

FIGURE 2

Average flash-evoked scotopic ERG peak A-wave and B-wave amplitudes at ∼2 months after impact. (A) A-wave peak amplitudes, compared across the three brightest light intensities, were similar for sham-vehicle, impact-vehicle, and impact-ral10 mice, but were increased for the impact-ral5 mice (p = 0.0006 relative to sham). (B) B-wave peak amplitudes, compared across the six brightest light intensities, were reduced for impact-vehicle mice (p = 2.8 × 10− 5 relative to sham). Impact mice treated with 5 mg/kg raloxifene showed rescue of the B-wave deficit, with amplitudes increased compared to impact-vehicle mice (p = 2.0 × 10− 10). Raloxifene at 10 mg/ml did not yield rescue, with B-wave amplitudes similar to impact-vehicle mice and significantly less than in sham (p = 3.2 × 10− 5). Errors bars are SEMs. Animal numbers: 15 sham-vehicle mice, 17 impact-vehicle mice, 17 impact-ral5 mice, and 14 impact-ral10 mice.