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. 2021 Oct 29;12:746206. doi: 10.3389/fpsyt.2021.746206

Figure 6.

Figure 6

Genomic location of significant clumps of SNPs in the IL6 gene influencing suicidal phenotypes in interaction with different types of stress. Logistic regression models on the interaction between IL6 and childhood adversities on lifetime suicide attempts yielded three significant clumps (one for additive and two for dominant models) (A). Linear regression models on the interaction between IL6 and childhood adversities on current suicidal ideation (SI-BSI03) yielded three significant clumps (two for additive and one for dominant models) all consisting of one SNP each (B). Linear regression models on the interaction between IL6 and childhood adversities on current thoughts of death (ToD-BSI21) yielded three significant clumps (C). Linear regression models on the interaction between IL6 and recent negative life events (RLE) on current suicidal ideation (SI-BSI03) yielded three significant clumps (D). Top SNPs are marked with blue for each clump. The exons are marked with grey rectangles on the gene. Figures are based on diagrams generated by LDlink, LDmatrix Tool (https://ldlink.nci.nih.gov/?tab=ldmatrix).