Table 2.
Interaction effects between IL6 variation and childhood adversities on lifetime suicide attempts.
| IL6 × CHA: lifetime suicide attempts | ||||||
|---|---|---|---|---|---|---|
| SNP | OR | SE | 95%CI | Minor allele | Risk/protective | p |
| ADDITIVE MODEL | ||||||
| rs2069835 | 0.47 | 0.21 | 0.31–0.72 | C | Protective | 0.0004 |
| rs13438415 | 0.52 | 0.21 | 0.35–0.79 | A | Protective | 0.0020 |
| rs2069824 | 0.53 | 0.22 | 0.35–0.81 | C | Protective | 0.0032 |
| DOMINANT MODEL | ||||||
| rs1880241 | 2.04 | 0.18 | 1.44–2.90 | G | Risk | 0.0001 |
| rs62449494 | 1.94 | 0.18 | 1.38–2.74 | G | Risk | 0.0002 |
| rs7805828 | 2.01 | 0.18 | 1.42–2.83 | A | Risk | 0.0001 |
| rs2069835 | 0.46 | 0.22 | 0.30–0.70 | C | Protective | 0.0003 |
| rs7801617 | 0.64 | 0.22 | 0.41–0.99 | A | Protective | 0.0439 |
| rs13438415 | 0.51 | 0.21 | 0.33–0.77 | A | Protective | 0.0014 |
| rs2069824 | 0.51 | 0.22 | 0.34–0.79 | C | Protective | 0.0022 |
Top SNP of each clump are marked in bold, member SNPs in each clump are listed under the top SNP. P-values surviving corrections for multiple testing are shown. CHA, childhood adversity; OR, odds ratio; SE, standard error; 95%CI, 95% confidence interval.