Table 4.
Interaction effects between IL6 variation and childhood adversities on current thoughts of death.
| IL6 × CHA: current suicide risk | ||||||
|---|---|---|---|---|---|---|
| SNP | Beta | SE | 95%CI | Minor allele | Risk/protective | p |
| Current thoughts of death (ToD-BSI21) | ||||||
| ADDITIVE MODEL | ||||||
| rs1474348 | −0.15 | 0.04 | −0.24 to −0.07 | C | Protective | 0.0005 |
| rs6461662 | −0.09 | 0.04 | −0.18 to −0.01 | G | Protective | 0.0273 |
| rs6963591 | −0.09 | 0.04 | −0.18 to −0.01 | A | Protective | 0.0315 |
| rs6963866 | −0.09 | 0.04 | −0.18 to −0.01 | C | Protective | 0.0290 |
| rs1546762 | −0.09 | 0.04 | −0.18 to −0.01 | C | Protective | 0.0314 |
| rs1546763 | −0.09 | 0.04 | −0.18 to −0.01 | G | Protective | 0.0314 |
| rs4719713 | −0.09 | 0.04 | −0.18 to −0.01 | G | Protective | 0.0302 |
| rs1880241 | 0.09 | 0.04 | 0.01 to 0.17 | G | Risk | 0.0240 |
| rs1880242 | −0.10 | 0.04 | −0.18 to −0.01 | G | Protective | 0.0213 |
| rs2002792 | 0.11 | 0.04 | 0.02 to 0.19 | G | Risk | 0.0142 |
| rs7802307 | −0.15 | 0.04 | −0.23 to −0.06 | T | Protective | 0.0009 |
| rs1800795 | −0.15 | 0.04 | −0.24 to −0.07 | C | Protective | 0.0006 |
| rs2069832 | −0.15 | 0.04 | −0.24 to −0.07 | A | Protective | 0.0006 |
| rs1474347 | −0.15 | 0.04 | −0.24 to −0.07 | C | Protective | 0.0005 |
| rs1554606 | −0.15 | 0.04 | −0.23 to −0.06 | T | Protective | 0.0006 |
| rs2069845 | −0.15 | 0.04 | −0.23 to −0.06 | G | Protective | 0.0005 |
| rs7787893 | −0.13 | 0.04 | −0.22 to −0.05 | A | Protective | 0.0019 |
| rs35436671 | −0.13 | 0.04 | −0.22 to −0.05 | G | Protective | 0.0023 |
| rs12700390 | −0.13 | 0.04 | −0.22 to −0.04 | G | Protective | 0.0030 |
| rs12700391 | −0.13 | 0.04 | −0.22 to −0.04 | C | Protective | 0.0030 |
| rs7781534 | −0.13 | 0.04 | −0.22 to −0.04 | A | Protective | 0.0031 |
| rs4722168 | −0.13 | 0.04 | −0.22 to −0.04 | G | Protective | 0.0033 |
| rs1581497 | −0.13 | 0.04 | −0.22 to −0.05 | C | Protective | 0.0028 |
| rs1829927 | −0.13 | 0.04 | −0.22 to −0.04 | G | Protective | 0.0031 |
| DOMINANT MODEL | ||||||
| rs4719714 | 0.22 | 0.06 | 0.09 to 0.34 | T | Risk | 0.0007 |
| rs56728381 | 0.21 | 0.06 | 0.09 to 0.34 | C | Risk | 0.0008 |
| rs73683966 | 0.20 | 0.06 | 0.08 to 0.33 | G | Risk | 0.0016 |
| rs73683967 | 0.20 | 0.06 | 0.08 to 0.33 | G | Risk | 0.0013 |
| rs10499563 | 0.21 | 0.06 | 0.09 to 0.34 | G | Risk | 0.0008 |
| RECESSIVE MODEL | ||||||
| rs2069845 | −0.27 | 0.07 | −0.42 to −0.13 | G | Protective | 0.0002 |
| rs7802307 | −0.25 | 0.08 | −0.40 to −0.10 | T | Protective | 0.0012 |
| rs1800795 | −0.27 | 0.08 | −0.42 to −0.12 | C | Protective | 0.0005 |
| rs2069832 | −0.26 | 0.08 | −0.41 to −0.11 | A | Protective | 0.0007 |
| rs1474348 | −0.26 | 0.08 | −0.41 to −0.11 | C | Protective | 0.0006 |
| rs1474347 | −0.26 | 0.08 | −0.41 to −0.11 | C | Protective | 0.0006 |
| rs1554606 | −0.27 | 0.07 | −0.42 to −0.13 | T | Protective | 0.0002 |
| rs7787893 | −0.23 | 0.08 | −0.37 to −0.08 | A | Protective | 0.0028 |
| rs35436671 | −0.23 | 0.08 | −0.38 to −0.07 | G | Protective | 0.0041 |
| rs12700390 | −0.22 | 0.08 | −0.38 to −0.06 | G | Protective | 0.0056 |
| rs12700391 | −0.22 | 0.08 | −0.38 to −0.06 | C | Protective | 0.0056 |
| rs7781534 | −0.22 | 0.08 | −0.38 to −0.07 | A | Protective | 0.0054 |
| rs4722168 | −0.22 | 0.08 | −0.38 to −0.07 | G | Protective | 0.0053 |
| rs1581497 | −0.22 | 0.08 | −0.38 to −0.07 | C | Protective | 0.0049 |
| rs1829927 | −0.22 | 0.08 | −0.38 to −0.07 | G | Protective | 0.0054 |
Top SNP of each clump are marked in bold, other SNPs in each clump are listed under the top SNP. P-values surviving corrections for multiple testing are shown. SE, standard error; 95%CI, 95% confidence interval.