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. 2021 Oct 29;12:770518. doi: 10.3389/fphar.2021.770518

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Copyright © 2021 Landersdorfer and Nation.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bacterial counts (CFU/mL) of Pseudomonas aeruginosa wild-type reference strain PAO1 which is non-hypermutable (A) and its PAOΔmutS isogenic hypermutable strain (B) in the hollow-fibre in vitro infection model over 10 days (Landersdorfer et al., 2018). Each strain had a meropenem MIC of 1 mg/L and each was exposed to two meropenem dosing regimens (3 g/day as a continuous infusion [red triangles] generating exposure of 100%fT_>5×MIC and 1 g as 30 min intravenous infusion every 8 h [inverted blue triangles] generating exposure of 36%fT_>5×MIC). The respective growth controls are shown as black circles. The figure is adapted from Figure 4 in the original publication of Landersdorfer et al., 2018.