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. 2021 Oct 16;155(2):193–202. doi: 10.1007/s11060-021-03867-8

Table 2.

Eight most frequently used chemotherapy drugs with evaluable responses

Drug n CR PR SD PD ORR (%) RR (%) Median duration of response Median time to progression
Etoposide 54 0 3 18 33 5.6 38.9 0 (CI 0; 5.04) 3.54 (CI 1.64; 12.45)
Temozolomide 46 1 3 9 33 8.7 28.3 0 (CI 0; 0.79) 2.64 (CI 1.59; 8.09)
Trofosfamide 30 0 1 10 19 3.3 36.7 0 (CI 0; 6.13) 4 (CI 1.81; 11.44)
Carboplatin 20 0 1 7 12 5 40 0 (CI 0; 4.69) 3.93 (CI 1.71; 12.87)
Cyclophosphamide 13 0 0 5 8 0 38.5 0 (CI 0; 2.24) 3.17 (CI 1.93; 8.97)
Vincristine 12 0 0 4 8 0 33.3 0 (CI 0; 2.64) 3.29 (CI 2.2; 7.46)
Sirolimus 8 0 0 4 4 0 50 1.28 (CI 0; 5.95) 11.51 (CI 4.22; 14)
Topotecan 7 0 0 0 7 0 0 0 (CI 0; 0) 1.32 (CI 0.55; 1.61)

n Number of times used, CR complete remission, PR partial remission, SD disease stabilization, PD progressive disease, ORR objective response-rate, RR response-rate, CI 95% confidence-interval