Table 2.
Drug concentration pre-diet/pre-surgery and post-surgery (A), as well as pre-diet and post-diet (B)
| Individuals N |
Dose-adjusted drug concentrationa Median (IQR) |
||||
|---|---|---|---|---|---|
| Pre-diet/pre-surgery | Post-surgerya | P-value | |||
| A | |||||
| SSRI | Citalopram/escitalopram | 17 | 133 (80–179) | 108 (68–167) | 0.015 |
| Fluoxetine | 14 | 221 (157–371) | 294 (193–570) | 0.084 | |
| Paroxetine | 1 | 22 (N/A) | 167 (N/A) | N/A | |
| Sertraline | 11 | 51 (27–84) | 25 (18–48) | 0.041 | |
| SNRI | Duloxetine | 8 | 127 (96–203) | 82 (30–103) | 0.015 |
| Venlafaxine | 16 | 173 (88–443) | 168 (57–369) | 0.47 | |
| TCA | Amitriptyline | 2 | 283 (N/A) | 218 (N/A) | N/A |
| Clomipramine | 1 | 578 | 329 | N/A | |
| Other | Hydroxybupropion | 2 | 3,997 (N/A) | 3,298 (N/A) | N/A |
| Mianserine | 3 | 255 (N/A) | 183 (N/A) | N/A | |
| Mirtazapine | 6 | 148 (131–170) | 88 (82–143) | 0.046 | |
| Antipsychotics | Olanzapine | 1 | 113 (N/A) | 106 (N/A) | N/A |
| Quetiapine | 1 | 848 (N/A) | 239 (N/A) | N/A | |
| Antiepileptics | Gabapentin | 2 | 34 (N/A) | 35 (N/A) | N/A |
| Lamotrigine | 4 | 17 (15–23) | 18 (15–27) | N/A | |
| Pregabalin | 6 | 8.5 (5.8–16) | 13 (8–18) | 0.25 | |
| Topiramate | 2 | 33 (N/A) | 37 (N/A) | N/A | |
| Valproic acid | 2 | 533 (N/A) | 529 (N/A) | N/A | |
| B | |||||
| SSRI | Citalopram/escitalopram | 17 | 133 (80–179) | 124 (71–215) | 0.87 |
| Fluoxetine | 12 | 259 (147–379) | 263 (182–333) | 0.31 | |
| Paroxetine | 1 | 22 (N/A) | 69 (N/A) | N/A | |
| Sertraline | 8 | 66 (43–87) | 39 (23–53) | 0.012 | |
| SNRI | Duloxetine | 8 | 127 (96–203) | 105 (64–235) | 0.21 |
| Venlafaxine | 14 | 172 (79–399) | 132 (87–215) | 0.20 | |
| TCA | Amitriptyline | 2 | 283 (N/A) | 279 (N/A) | N/A |
| Clomipramine | 1 | 578 (N/A) | 449 (N/A) | N/A | |
| Other | Hydroxybupropion | 1 | 2,732 (N/A) | 3,067 (N/A) | N/A |
| Mianserine | 3 | 255 (N/A) | 201 (N/A) | N/A | |
| Mirtazapine | 4 | 138 (120–157) | 76 (50–102) | N/A | |
| Antipsychotics | Olanzapine | 0 | |||
| Quetiapine | 1 | 848 (N/A) | 260 (N/A) | N/A | |
| Antiepileptics | Gabapentin | 2 | 28 (N/A) | 43 (N/A) | N/A |
| Lamotrigine | 4 | 17 (15–25) | 23 (19–29) | N/A | |
| Pregabalin | 5 | 9.5 (7–21) | 25 (8–33) | N/A | |
| Topiramate | 3 | 39 (N/A) | 31 (N/A) | N/A | |
| Valproic acid | 1 | 737 (N/A) | 759 (N/A) | N/A | |
Significant P-values are bolded
DDD defined daily dose, IQR interquartile range, N/A not applicable, SNRI serotonin–norepinephrine reuptake inhibitor, SSRI selective serotonin reuptake inhibitor, TCA tricyclic antidepressant
aµmol/L for antiepileptics and nmol/L for other substances, the concentrations adjusted for dose in DDDs (see WHO Collaborating Centre for Drug Statistics Methodology [11]), with statistical comparisons (pre versus post) performed when n ≥ 6
bLast observation carried forward, at a median 379 (IQR 214–406) days after surgery