Table 3.
Case No | Surgical procedure | Substance | Baseline | Post-surgery | Health consequences related to changed drug concentrations | |||
---|---|---|---|---|---|---|---|---|
Drug dose | Concentration | Day | Drug dose | Concentration | ||||
1 | GBP | Citalopram | 10 mg | 137 nmol/L | +252 | 10 mg | 69 nmol/L | Reported increased dose 3–4 weeks before the final sampling because of psychiatric symptoms |
+374 | 20 mg | 158 nmol/L | ||||||
2 | GBP | Citalopram | 10 mg | 89 nmol/l | +178 | 10 mg | 42 nmol/L | Reported increased dose 2 weeks before the final sampling because of depressive symptoms |
+386 | 20 mg | 90 nmol/L | ||||||
3 | GBP | Mirtazapine | 15 mg | 96 nmol/L | +68 | 15 mg | 30 nmol/L | Reported that sertraline had been switched to escitalopram after the first post-surgery sampling without beneficial effects, changed back to sertraline |
+368 | 30 mg | 203 nmol/L | ||||||
Sertraline | 200 mg | 130 nmol/L | +68 | 200 mg | 66 nmol/L | |||
+368 | 200 mg | 78 nmol/L | ||||||
4 | Sleeve | Mirtazapine | 30 mg | 140 nmol/L | 213 | 30 mg | 87 nmol/L | Reported increased dose 2 months before the final sampling because of the psychiatric condition |
393 | 45 mg | 119 nmol/L |
GBP gastric bypass
*Doubled/halved