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. 2021 Jun 4;60(11):1407–1421. doi: 10.1007/s40262-021-01024-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 7 — Simulated N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration–time profiles under vericiguat 10 mg on top of standard of care (SoC) or for SoC alone (a) and simulated absolute NT-proBNP change compared with SoC (b). Solid lines: simulated NT-proBNP time courses for vericiguat 10 mg. Dashed lines: simulations for the corresponding SoC arm. [NT-proBNP]_baseline considered for simulation: 250 pg/mL (gray), 500 pg/mL (orange), 1000 pg/mL (green), 3000 pg/mL (purple), 5000 pg/mL (light blue), and 10,000 pg/mL (dark blue)