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. 2021 Nov 11;11:22099. doi: 10.1038/s41598-021-01568-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Flow cytometry-based pitting quantification. uRBCs and P.f.-RBCs were collected and analyzed by flow cytometry before and after passing through the microfluidic devices. Cells were gated according to the strategy described in Supplementary Fig. S3. (A) Representative dot plots of uRBCs (DAPI^-RESA^-), autofluorescent uRBC (DAPI^-RESA^medium), P.f.-RBCs (DAPI⁺RESA⁺), O-iRBCs (DAPI^-RESA^high) before (No chip) and after passing through microfluidic device models 1 and 2. This figure corresponds to one experiment out of seven. Twelve devices were used in each experiment (six of model 1 and six of model 2). (B) Frequencies of DAPI^-RESA^high cells from model 1 and model 2 between uninfected and infected cells before and after passing through the devices were compared. Data represent the mean and standard error of the mean obtained from seven independent experiments. Statistical significance was assessed by a t test with Wilcoxon signed-rank post-test, being considered statistical significance (*p value < 0.05).