Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 11;12:6540. doi: 10.1038/s41467-021-26750-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — 7-month-old CD4-CKO mice and CD4-Cre littermates were orally gavaged with Smo inhibitor, sonidegib (100 mg/kg) for 4 months. a Pathological score (n = 6). b Gross images. c X‐ray images. (b and c) Scale bars: 1 cm. d Femur bone mineral density (BMD). (n = 6) e H&E staining of knee joints. f SOFG staining of knee joints. g and h μ-CT radiographs of knee joint (g) and spine (h) of 11-month-old mice. Arrows show ectopic new bone formation. Scale bars: 2.5 cm. i Immunohistochemical staining of pSmad1/5 protein levels in knee joint of 11-month-old mice. e, f, i Scale bars: 100 μm. a, d Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001, determined by two-tailed Student’s t-test. b, c, e–i Data are representative of three independent biological replicates. j The mechanism of AS-like bone disease in CD4-CKO mice.