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. 2021 Nov 11;12:6544. doi: 10.1038/s41467-021-26820-9

Fig. 9. Proposed model for regulation of nodule organogenesis by nitrate.

Fig. 9

In low nitrate, NLP signalling contributes to regulation of symbiotic genes, which stimulate cytokinin biosynthesis, ensuring robust nodule maturation and onset of nitrogen fixation. In high nitrate, NLP-dependent nitrate signalling inhibits expression of symbiotic genes and symbiotic cytokinin biosynthesis that is crucial for nodule organogenesis. Nodulation is thus balanced between a permissive low-nitrate state where high cytokinin levels can accumulate, or a restrictive state with low root cytokinin.