TABLE 2.
Association statistics for rheumatoid arthritis susceptibility and genetic variants.
| Genotypes | RA | Normal | OR (95% CI) | p-value |
|---|---|---|---|---|
| rs9268839, located at 6p21.32, HLA-DRB9 | ||||
| AA | 262 (16.30%) | 494 (31.27%) | 1 (reference) | 1.46 × 10−27 a |
| GA | 840 (52.27%) | 780 (49.37%) | 2.03 (1.69–2.44) | |
| GG | 505 (31.43%) | 306 (19.37%) | 3.11 (2.52–3.85) | |
| GG vs. GA + AA | 505 (31.43%) | 306 (19.37%) | 1.91 (1.62–2.25) | 4.77 × 10−15 |
| GG + GA vs. AA | 1,345 (83.70%) | 1,086 (68.73%) | 2.34 (1.96–2.78) | 2.01 × 10−23 |
| G allele | 1850 (57.56%) | 1,392 (44.05%) | 1.72 (1.56–1.9) | 3.86 × 10−27 |
| rs9275376, located at 6p21.32, HLA-DQB1 | ||||
| GG | 887 (55.20%) | 1,128 (71.39%) | 1 (reference) | 1.26 × 10−20 a |
| TG | 636 (39.58%) | 408 (25.82%) | 1.98 (1.7–2.32) | |
| TT | 84 (5.23%) | 44 (2.78%) | 2.43 (1.65–3.62) | |
| TT vs TG + GG | 84 (5.23%) | 44 (2.78%) | 1.93 (1.31–2.86) | 5.58 × 10−4 |
| TT + TG vs GG | 720 (44.80%) | 452 (28.61%) | 2.03 (1.74–2.35) | 2.05 × 10−21 |
| T allele | 804 (25.02%) | 496 (15.70%) | 1.79 (1.58–2.03) | 2.01 × 10−20 |
| rs7752903, located at 6q23.3, TNFAIP3 | ||||
| TT | 1,408 (87.62%) | 1,445 (91.46%) | 1 (reference) | 4.19 × 10−4 a |
| GT | 193 (12.01%) | 134 (8.48%) | 1.48 (1.16–1.88) | |
| GG | 6 (0.37%) | 1 (0.06%) | 6.16 (0.75–283.06) | |
| GG vs GT + TT | 6 (0.37%) | 1 (0.06%) | 5.92 (0.72–272.02) | 0.1246 |
| GG + GT vs TT | 199 (12.38%) | 135 (8.54%) | 1.51 (1.19–1.92) | 4.12 × 10−4 |
| G allele | 205 (6.38%) | 136 (4.30%) | 1.51 (1.21–1.91) | 2.33 × 10−4 |
| rs4947332, located at 6p21.33, Tag-SNPs of HLA-DRB1*04:07 | ||||
| CC | 1,537 (95.64%) | 1,546 (97.85%) | 1 (reference) | 5.51 × 10−4 a |
| TC | 68 (4.23%) | 34 (2.15%) | 2.01 (1.31–3.15) | |
| TT | 2 (0.12%) | 0 (0.00%) | — | |
| TT vs TC + CC | 2 (0.12%) | 0 (0.00%) | — | 0.4998 |
| TT + TC vs. CC | 70 (4.36%) | 34 (2.15%) | 2.07 (1.35–3.24) | 4.53 × 10−4 |
| T allele | 72 (2.24%) | 34 (1.08%) | 2.11 (1.38–3.28) | 2.67 × 10−4 |
| rs1414273, located at 1p13.1 within miR-548ac | ||||
| CC | 284 (17.67%) | 307 (19.43%) | 1 (reference) | 4.84 × 10−4 a |
| TC | 735 (45.74%) | 798 (50.51%) | 1.00 (0.82–1.21) | |
| TT | 588 (36.59%) | 475 (30.06%) | 1.34 (1.09–1.65) | |
| TT vs TC + CC | 588 (36.59%) | 475 (30.06%) | 1.34 (1.15–1.56) | 9.35 × 10−5 |
| TT + TC vs CC | 1,323 (82.33%) | 1,273 (80.57%) | 1.12 (0.94–1.35) | 0.2023 |
| T allele | 1911 (59.46%) | 1748 (55.32%) | 1.18 (1.07–1.31) | 9.04 × 10−4 |
| rs2620381, located at 15q15.1 within miR-627 | ||||
| CC | 9 (0.56%) | 20 (1.27%) | 1 (reference) | 7.27 × 10−3 a |
| AC | 236 (14.69%) | 278 (17.59%) | 1.89 (0.8–4.79) | |
| AA | 1,362 (84.75%) | 1,282 (81.14%) | 2.36 (1.02–5.91) | |
| AA vs. AC + CC | 1,362 (84.75%) | 1,282 (81.14%) | 1.29 (1.07–1.56) | 7.21 × 10−3 |
| AA + AC vs. CC | 1,598 (99.44%) | 1,560 (98.73%) | 2.28 (0.99–5.7) | 0.04035 |
| A allele | 2,960 (92.10%) | 2,842 (89.94%) | 1.3 (1.09–1.56) | 0.00285 |
a
indicating p-values from genotype-based chi-square or Fisher exact test (when N<=5) models. All the OR and p-value are calculated compared with homogeneous protective allele (reference row as the table). Chi-square or Fisher exact test was applied as the statistical approach so that ORs are comparative between different models.