TABLE 4.
Epistasis analysis to identify SNP-SNP interaction in rheumatoid arthritis susceptibility.
| Epistasis | SNP Genotypes | RA | Control | OR | P | |
|---|---|---|---|---|---|---|
| rs4947332 & rs9275376 | rs4947332 | rs9275376 | ||||
| CC | GG | 885 | 1,119 | 1 (reference) | ||
| CT + TT | GG | 2 | 9 | 0.38 (0.1–1.38) | 0.164 | |
| CC | GT + TT | 652 | 427 | 1.93 (1.66–2.24) | 6.59 × 10−18 | |
| CT + TT | GT + TT | 68 | 25 | 3.35 (2.12–5.31) | 6.70 × 10−8 | |
| rs4947332 & rs5997893 | rs4947332 | rs5997893 | ||||
| CC | GG | 330 | 392 | 1 (reference) | ||
| CT + TT | GG | 9 | 9 | 1.19 (0.49–2.89) | 0.821 | |
| CC | GT + TT | 1,207 | 1,154 | 1.24 (1.05–1.47) | 0.012 | |
| CT + TT | GT + TT | 61 | 25 | 2.83 (1.75–4.58) | 1.36 × 10−5 | |
| rs7752903 & rs2967897 | rs7752903 | rs2967897 | ||||
| TT | CC | 953 | 1,050 | 1 (Reference) | ||
| TG + GG | CC | 148 | 93 | 1.75 (1.33–2.29) | 5.76 × 10−5 | |
| TT | CT + TT | 455 | 395 | 1.27 (1.08–1.49) | 0.00370 | |
| TG + GG | CT + TT | 51 | 42 | 1.33 (0.88–2.01) | 0.20705 | |
Five significant epistasis effects were selected to show the increased or decreased risk effect. rs4947332 located in C2 upstream (HLA-DRB1); rs9275376 located in HLA-DQB1 upstream; rs5997893 located in miR-3928; rs7752903 located downstream of TNFAIP3 and rs2967897 located in miR-5695.