TABLE 5.
Cumulative risk effect of rheumatoid arthritis increased as more risk alleles were carried by patients.
| No. of risk alleles a | RA | Normal | OR (95% CI) | P |
|---|---|---|---|---|
| 1 | 4 | 17 | 1.00 (Reference) | — |
| 2 | 65 | 133 | 1.77 (0.63–4.99) | 0.348209 |
| 3 | 206 | 340 | 2.19 (0.80–5.97) | 0.129698 |
| 4 | 388 | 466 | 3.00 (1.10–8.15) | 0.031822 |
| 5 | 411 | 359 | 4.12 (1.51–11.21) | 0.002819 |
| 6 | 344 | 185 | 6.68 (2.44–18.27) | 6.30 × 10−05 |
| 7 | 138 | 67 | 7.36 (2.62–20.66) | 4.26 × 10−05 |
| 8 | 46 | 10 | 15.38 (4.69–50.49) | 1.00 × 10−06 |
a
individuals carrying 0 or more than 9 risk alleles were not found in our dataset. We only found 8 individuals carrying 9 risk alleles (5 RA and 3 normal), which is not stable for the estimation and therefore ignored in this table. rs1414273 (T), rs4947332 (T), rs9268839 (G), rs9275376 (T), rs7752903 (G) and rs2620381 (A) were included in the analysis. Risk alleles are shown in the parentheses following SNPs.