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. 2021 Oct 29;15:758251. doi: 10.3389/fnbeh.2021.758251

FIGURE 1.

FIGURE 1

SNI induces mechanical sensitivity and depressive-like behavior. (A) Mechanical allodynia is evident in male and female mice following SNI, but not sham surgery, 2- and 3-week post-injury (n = 16 for BL and WK2; n = 8 for WK3/sex/condition). (B) SNI increases immobility on the forced swim test in male mice 2-week post-surgery, while immobility increases in female SNI mice 3-week post-surgery (n = 8/sex/condition). (C) SNI increases immobility on the tail suspension test in female mice 3-week post-surgery (n = 8/sex/condition). (D) Female SNI mice spend less time in the center area of the open field 3-week post-surgery (n = 8/sex/condition). (E) SNI did not alter sucrose preference in male and female mice at any of the tested timepoints (n = 7–8/sex/condition). *p < 0.05; **p < 0.001; ***p < 0.0001.