Table 2.

Main GFs involved in the regeneration of vascular networks.

GFs	Main function	Ref.
VEGF	The key regulator of angiogenesis during embryogenesis; promoting ECs migration, proliferation, vascular permeability, and degeneration of ECM through binding to the receptors with tyrosine kinase activity	[200,201]
bFGF	Inducing plasminogen activator and collagenase activity; a strong synergistic action with VEGF accelerating ECs migration	[202]
PDGF-B	Stabilizing and enclosing the channels of ECs, leading to the maturation of blood vessels	[203]
ANG-1	Maintaining the interaction between ECs and surrounding supporting cells and the stability of blood vessel structure	[184]

Abbreviations: ANG-1 - angiopoietin-1, bFGF - basic fibroblast growth factors, GFs - growth factors, PDGF-B - platelet-derived GF-B, VEGF - vascular endothelial growth factors.