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. 2021 Nov 11;11:22119. doi: 10.1038/s41598-021-01652-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the reproducibility of the metabolic alterations induced by xenobiotics. Upset plots to visualize the intersecting sets of metabolites that appeared statistically significant (p value < 0.05) in the t test analysis between acetaminophen and citric acid (a) or valproate and citric acid (b) from one up to five batches. Numbers on the set size squares indicate the metabolites that are statistically significant between compound comparisons in each batch. (c-d) Box plots of the fold change (FC) in the levels of the metabolites that were statistically significant in the t test between valproate or acetaminophen treatment versus citric acid in all five batches. FC > 1 means metabolite increase and FC < 1 decrease. Each dot represents the FC in a specific batch and passage.