Table 1.
Comparison of Demographic and Radiographic Characteristics of Patients with Aquaporin-4 IgG Optic Neuritis (AQP4-IgG-ON) and Myelin Oligodendrocyte Glycoprotein IgG (MOG-IgG-ON)
| Demographics and Radiological Findings |
AQP4-IgG-ON No. /Total No. (%) |
MOG-IgG-ON No. /Total No. (%) |
MOG-IgG-ON vs. APQ4-IgG-ON P valuea |
|---|---|---|---|
| Median age at ON onset (range), y | 44 (7-78) | 32 (2-79) | .007 |
| Female | 63/74 (85) | 50/80 (63) | .005 |
| Ethnicity, % | |||
| White | 69 | 58 | |
| Black | 22 | 6 | |
| Asian | 3 | 18 | |
| Hispanic | 1 | 11 | |
| Other/unknown | 5 | 8 | |
| Optic chiasm involvement | 15/74 (20) | 13/80 (16) | .66 |
| Female | 12/15 (80) | 9/13 (70) | |
| White | 11/15 (73) | 9/13 (70) | |
| Black | 3/15 (20) | 0 | |
| Asian | 0 | 1/13 (8) | |
| Hispanic | 1/15 (7) | 2/13 (15) | |
| Other | 0 | 1/13 (8) | |
| Prior ON without chiasm involvement | 1/15 (7) | 1/13 (8) | |
| Chiasmal involvement with longitudinally extensive optic nerve lesion | 2/15 (13) | 7/13 (54) | .04 |
| Posterior optic chiasm lesion | 12/15 (80) | 3/13 (23) | 0.008 |
| Extra-optic nerveb involvement and ON | 14/74 (19) | 17/80 (21) | 0.72 |
| Without chiasmal involvement | 12/59 (20) | 16/67 (24) | 0.63 |
| With chiasmal involvement | 2/15 (13) | 1/13 (8) | 0.63 |
a
Statistical comparison between MOG-IgG-ON and AQP4-IgG-ON.
b
Extra-optic nerve refers to cases with other symptomatic MRI lesions, such as transverse myelitis or area postrema involvement at the time of ON.