Table 2.

Final logistic regression model for individual studies and pooled data

Effect	Odds ratio estimate	95% Confidence interval (lower, upper)	p value
Orthopedic (hard tissue) surgery—bunionectomy study
Treatment (oliceridine vs. morphine)a	0.499	0.255, 0.976	0.0422
Plastic (soft tissue) surgery—abdominoplasty study
Treatment (oliceridine vs. morphine)b	0.542	0.250, 1.175	0.1209
Baseline pain scoreb	1.279	1.037, 1.576	0.0213
Analysis from the pooled studies
Treatment (oliceridine vs. morphine)c	0.507	0.304, 0.844	0.009

^aThe final model included treatment, baseline pain score, and Sum of Pain Intensity Differences (SPID) from baseline to 48 h (SPID-48) as main effects, and the baseline pain score and SPID-48 interaction

^bThe final model included treatment and baseline pain score as main effects

^cThe final model included treatment, study identifier, baseline pain score, and SPID-48 or SPID from baseline to 24 h (SPID-24), baseline pain score and study identifier interaction, and baseline pain score and SPID-48/-24 interaction