Clinical characteristics and physical and cognitive assessments of patients enrolled in a substudy to evaluate serum biomarkers detected at pre- and postoperative states in control and delirium cohorts. (A) Study design and data collection; (B) Age, body mass index (BMI), and total cardiopulmonary bypass (CPB) time; (C) Patient-Reported Outcomes Measurement Information System (PROMIS) scores of the patients’ overall physical health, and mental and physical function reported at pre-op; (D) PROMIS cognitive score, sleep disturbance, and pain interference scores reported at pre-op; and (E) temporal evaluation of overall cognitive abilities and applied cognition from pre- to postoperative day (POD) 30, 90, and 180. Bars show mean ± standard deviation. Statistical significance was evaluated using a Mann-Whitney U test.