Table 1.

Summary table of the immune functions of iris cell types.

Cell	Immune function	References
Cells of haematopoietic origin
Dendritic cell (cDC subtype)	Antigen presentation, functionally immature when in situ	(10–16, 19, 22)
Tissue macrophage	Cytokine production and antigen presentation	(10, 11, 16, 24–27)
Mast cell	Sentinel function, immediate response to pathogens Cytokine production	(27, 29–33)
Parenchymal and stromal cells
Melanocyte	Response to PAMPs, limited cytokine production	(39–44)
Iris pigment epithelium	Response to PAMPs, limited cytokine production	(51, 52)
	Inhibition of T-cell activation, induction of T-reg cells	(55, 56, 58–60, 62, 66)