Why carry out this study?

Vaginal natural orifice transluminal endoscopic surgery (vNOTES) approach for benign uterine disease is feasible and safe according to previous studies, but the postoperative pain reduction effect of vNOTES is controversial.

This study aims to evaluate whether vNOTES could reduce postoperative pain compared to laparoendoscopic single-site (LESS) surgery on women requiring hysterectomy for benign disease.

What was learned from the study?

Postoperative abdominal pain did not differ between the two groups, but vaginal pain was higher in the vNOTES group compared to the LESS group.

vNOTES may not reduce postoperative pain, but further study is needed because the patient-controlled analgesia usage may have masked the postoperative pain difference.