Why carry out this study?

A multimodal treatment approach that layers treatments targeting different physiological pathways involved in migraine may improve outcomes in patients with chronic migraine.

OnabotulinumtoxinA and calcitonin gene–related peptide monoclonal antibodies (CGRP mAbs) act through different physiological mechanisms and are both effective and well tolerated when administered individually for the preventive treatment of migraine.

We collected real-world data from chronic migraine patients who received CGRP mAb treatment added to onabotulinumtoxinA treatment to investigate the safety, tolerability, and potential benefits of this combination treatment.

What was learned from the study?

Adding a CGRP mAb to onabotulinumtoxinA was safe and well tolerated, with no new safety signals identified.

Combination treatment significantly decreased monthly headache frequency and migraine-related disability compared with onabotulinumtoxinA alone.