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. 2021 Nov 11;12:6489. doi: 10.1038/s41467-021-26745-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The relationship between gene copy number and survival time for CCNE1, EGFR, and ERBB2 genes in the GCA cohort, where copy number of CCNE1 and ERBB2 genes were divided into three groups, high, low, and normal, and copy number of the EGFR gene was divided into two groups, high and normal. High high copy number of gene amplification, Low low copy number of gene amplification, Normal no gene amplification. b Survival analysis of different groups with three oncogene amplifications (CCNE1, EGFR, and ERBB2) in the cohort. The definition of high, low, and normal is the same as in a, and the p-value was calculated using the two-sided Log rank test. c Survival time of present and absent focal amplifications of three oncogenes in ecDNA (CCNE1, EGFR, and ERBB2) in the cohort. The p-value was calculated using the two-sided Log rank test. Source data are provided as a Source Data file for Fig. 4a–c.