TABLE 2.
Factors affecting OS and PFS.
| Parameters | OS |
PFS |
||||||
| HR | 95% CI |
P | HR | 95% CI |
P | |||
| Lower | Higher | Lower | Higher | |||||
| Univariable Cox regression | ||||||||
| Age (> 65 vs. ≤ 65 y | 1.275 | 0.716 | 2.270 | 0.409 | 0.898 | 0.507 | 1.588 | 0.710 |
| Sex (Male vs. Female) | 0.565 | 0.281 | 1.136 | 0.109 | 1.009 | 0.500 | 2.037 | 0.981 |
| Smoking history (Yes vs. No) | 1.704 | 0.868 | 3.345 | 0.122 | 1.026 | 0.520 | 2.024 | 0.940 |
| ECOG PS (2 vs. 0-1) | 1.742 | 0.959 | 3.163 | 0.068 | 1.583 | 0.877 | 2.856 | 0.127 |
| TNM stage (IV vs. III) | 7.110 | 3.121 | 16.197 | <0.001 | 5.370 | 2.524 | 11.425 | <0.001 |
| Pathology (Squamous vs. Adenocarcinoma) | 1.094 | 0.602 | 1.987 | 0.769 | 1.075 | 0.590 | 1.958 | 0.814 |
| EGFR status (Wild type vs. Mutation) | 1.752 | 0.994 | 3.008 | 0.052 | 2.394 | 1.335 | 4.294 | 0.003 |
| Liver metastases (Yes vs. No) | 1.110 | 0.545 | 2.260 | 0.774 | 1.225 | 0.609 | 2.460 | 0.570 |
| Brain metastases (Yes vs. No) | 24.647 | 7.496 | 81.034 | <0.001 | 6.492 | 2.652 | 15.894 | <0.001 |
| Multivariable Cox regression | ||||||||
| EGFR status (Wild type vs. Mutation) | 1.20 | 0.958 | 3.086 | 0.069 | 2.498 | 1.368 | 4.560 | 0.003 |
| TNM stage (IV vs. III) | 4.915 | 1.928 | 12.530 | 0.001 | 4.105 | 1.728 | 9.752 | 0.001 |
| Brain metastases (Yes vs. No) | 25.242 | 6.261 | 101.770 | <0.001 | 5.633 | 2.042 | 15.538 | 0.001 |
OS, overall survival; HR, hazard ratio; CI, confidence interval; PFS, progression-free survival. The bold values are less than 0.05.