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. 2021 Oct 29;11:728253. doi: 10.3389/fonc.2021.728253

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Copyright © 2021 Yang, Li, Till, Wang, Zhang, Wang, Huang, Li, Gao, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathologic and immunohistochemical findings. (A) Histopathologic analysis demonstrated (1) epidermal hyperkeratosis with intraepidermal edema and blister formation (2), basal and suprabasal apoptotic keratinocytes with focal confluent apoptosis, and (3) moderate perivascular lymphocytic infiltration in the superficial dermis. Immunostaining shows (B) PD-1-positive lymphocytes (anti-PD-1, ×200) and (C) no PD-L1-positive cells (anti-PD-L1, ×200). Immunostaining revealed (D) CD4+ (anti-CD4, ×200) and (E) CD8+ T cell infiltration (anti-CD8, ×200). Immunohistochemistry confirmed the absence of (F) B cells (anti-CD20, ×200) and (G) NK cells (anti-CD56, ×200).