Table 4.

The variability of ERG11 gene in clinical D. catenulata isolates.

Isolate	Missense mutation	Synonymous mutation				MICs  (μg/ml)
	Nucleotide mutation (amino acid mutation)					FZ a	VOR a	PZ a	IZ a
1	A428G (K143R)	C681T	C888A	C999T	C1164T	256	0.5	0.12	0.12
2	C378G (F126L)	C681T	C888A	C999T	C1164T	64	1	0.12	0.12
3		G306A	C852T			4	0.12	0.06	0.12
4		G306A	C852T			4	0.12	0.06	0.06
6	C378G (F126L)	C681T	C888A	C999T	C1164T	32	0.25	0.06	0.06
11						4	0.12	0.06	0.06
12	A428G (K143R)					64	0.25	0.12	0.12
13		G306A	C852T			4	0.06	0.03	0.06
15	C378G (F126L), G417K (L139F)	C681T	C888A	C999T	C1164T	256	4	0.12	0.12
16	C378G (F126L), G417K (L139F)	C681T	C888A	C999T	C1164T	128	1	0.06	0.12
17	C378G (F126L), G417K (L139F)	C681T	C888A	C999T	C1164T	64	0.5	0.06	0.06

^aFZ, Fluconazole; VOR, Voriconazole; PZ, Posaconazole; IZ, Itraconazole.