Fig. 1. Survival and organ enlargement of Rnaset2^−/− mice.

a Kaplan–Meier blot survival for Rnaset2^−/− (blue, n = 173) and control (gray, n = 102) mice. The median lifetime of Rnaset2^−/− mice is 31 weeks. For the survival curve, a confidence interval of 95% is estimated using the exponential Greenwood method. The alpha level was corrected using Bonferroni’s method by the number of comparisons (alpha = 0.05/3). b Comparison of organ weights from Rnaset2^−/− mice (n = 47 for spleen and liver, n = 40 for heart, n = 45 for kidney and n = 6 for brain) and from control mice (n = 30 for spleen, liver, heart and kidney and n = 21 for brain). Rnaset2^−/− mouse revealed a significant enlargement of spleen, liver, and heart (p < 0.0001, respectively). Brain weight was significantly reduced (p = 0.0336) and kidney remained unaltered (p = 0.1205). Data are represented as mean values ± SEM and p values are depicted as ****p < 0.0001, *p < 0.05 and not significant p ≥ 0.05. c Macroscopy picture of Rnaset2^−/− and control spleen (left) and liver (right) after PBS perfusion in 5-month-old representative mice. Rnaset2^−/− spleen and liver were enlarged in volume and showed a dark red color. Source data are provided as a Source Data file.