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. 2021 Nov 11;12:6530. doi: 10.1038/s41467-021-26880-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Light microscopic image of CD3 immunohistochemistry (IHC: CD3) revealed a perivascular T cell infiltration near the left ventricle (inlay, left image). Scale bar, 1 mm and 100 µm respectively. Corresponding T2-weighted coronary MRI (MRI: T2w) showed no remarkable alterations (middle image). Corresponding map of percentage signal enhancement (MRI: Gd-DTPA) revealed gadolinium enhancement in the region of perivascular T cell infiltration near the left ventricle in Rnaset2^−/− mice (red circles, right image). Representative images of n = 2 biological replicates for Rnaset2^−/− and control mice, respectively. b Representative magnetic resonance anatomical images (of n = 8 Rnaset2^−/− and control mice, respectively) in sagittal, coronal, and axial plane showing significant hippocampal atrophy (asterisk) in Rnaset2^−/− mice compared to controls. Ventricular enlargement, which may have been arisen due to shrinkage of hippocampus are shown with (arrows). c Percent area of hippocampus (left and right) with respect to whole brain area. The size of the hippocampus relative to the whole brain was significantly smaller (p = 0.0002). n = 8 Rnaset2^−/− and control mice from two independent experiments. Data depicted as the mean ± SEM. P value of one-way ANOVA are presented as ***p < 0.001. d T₂ relaxation time measurement in various brain regions displayed a significant increase in cortex, hippocampus and periventricular region of Rnaset2^−/− mice in n = 8 Rnaset2^−/− and control mice, respectively. Region of interest (ROI) selected for T₂ relaxation time measurements are shown in left images. ROI: (1) ventricle, (2) periventricular, (3) cortex, (4) hippocampus. Data depicted as the mean ± SEM. p values of one-way ANOVA are represented as *p < 0.05. e 3-dimensional reconstruction of the ventricular system in MRI showed an expansion in Rnaset2^−/− (right side) versus control mice (left side) as an indication of a general brain atrophy. Source data are provided as a Source data file.