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. 2021 Jul 28;9:157–167. doi: 10.1016/j.bioactmat.2021.07.025

Fig. 2.

Fig. 2

Biocompatibility and PTT efficacy of PIONs in vitro and in vivo. (A) Cell viability of A549 cells treated with different concentrations of PIONs with or without 808 nm laser irradiation (1 W/cm2) for 10 min. (B) Cell viability of A549 cells treated with PIONs or PIONs@pDNA with or without 808 nm laser irradiation (1 W/cm2, 10 min). (C) pDNA release profile in PBS (pH = 5.0) with intermittent NIR laser irradiation (808 nm, 1 W/cm2). (D) Cumulative plasmid release profile for PIONs@pDNA measured in PBS (pH = 7.4 or 5.0) at room temperature. (E) Photothermal imaging after injecting PIONs (1 mg/kg) into subcutaneous tumors. (F) is the temperature curve of (E). The tumor was exposed to NIR laser irradiation (808 nm, 1 W/cm2) for 5 min. The data are expressed as mean ± standard deviation (SD). The error bar is derived from triplicate measurements. ***p < 0.001, **p < 0.01, *p < 0.05.