Table 3.
Patient migraine characteristics and comorbidities in the 6 months pre- and post-erenumab stratified by persistence
| Pre-erenumab | Post-erenumab | |||||
|---|---|---|---|---|---|---|
| All (N = 4437) | Erenumab persistent (N = 1853) | Erenumab non-persistent (N = 2584) | All (N = 4437) | Erenumab persistent (N = 1853) | Erenumab non-persistent (N = 2584) | |
| Comorbidities | ||||||
| Asthma | 174 (3.9) | 68 (3.7) | 106 (4.1) | 176 (4.0) | 63 (3.4) | 113 (4.4) |
| Hypertension | 457 (10.3) | 186 (10.0) | 271 (10.5) | 425 (9.6) | 168 (9.1) | 257 (9.9) |
| Acute myocardial infarction | 8 (0.2) | 1 (0.1) | 7 (0.3) | 9 (0.2) | 3 (0.2) | 6 (0.2) |
| Ischemic stroke | 23 (0.5) | 7 (0.4) | 16 (0.6) | 20 (0.5) | 8 (0.4) | 12 (0.5) |
| Constipation | 76 (1.7) | 28 (1.5) | 48 (1.9) | 85 (1.9) | 29 (1.6) | 56 (2.2) |
| Irritable bowel syndrome | 48 (1.1) | 20 (1.1) | 28 (1.1) | 52 (1.2) | 26 (1.4) | 26 (1.0) |
| Complications of constipation | 44 (1.0) | 18 (1.0) | 26 (1.0) | 52 (1.2) | 19 (1.0) | 33 (1.3) |
| Anxiety | 646 (14.6) | 238 (12.8) | 408 (15.8) | 604 (13.6) | 224 (12.1) | 380 (14.7) |
| Depression | 500 (11.3) | 192 (10.4) | 308 (11.9) | 477 (10.8) | 173 (9.3) | 304 (11.8) |
| Other (non-migraine) headaches | 810 (18.3) | 299 (16.1) | 511 (19.8) | 584 (13.2) | 201 (10.8) | 383 (14.8) |
| Low back pain | 463 (10.4) | 192 (10.4) | 271 (10.5) | 440 (9.9) | 158 (8.5) | 282 (10.9) |
| Osteoarthritis/spondylosis | 393 (8.9) | 168 (9.1) | 225 (8.7) | 431 (9.7) | 166 (9.0) | 265 (10.3) |
| Fibromyalgia | 171 (3.9) | 62 (3.3) | 109 (4.2) | 146 (3.3) | 53 (2.9) | 93 (3.6) |
| No comorbidities | 2056 (46.3) | 893 (48.2) | 1163 (45.0) | 2207 (49.7) | 972 (52.5) | 1235 (47.8) |
| Migraine characteristics, n (%) | ||||||
| Migraine with aura, including persistent aura | 915 (20.6) | 372 (20.1) | 543 (21.0) | 700 (15.8) | 287 (15.5) | 413 (16.0) |
| Migraine with aura, excluding persistent aura | 890 (20.1) | 364 (19.6) | 526 (20.4) | 682 (15.4) | 280 (15.1) | 402 (15.6) |
| Chronic migraine | 2904 (65.4) | 1216 (65.6) | 1688 (65.3) | 2531 (57.0) | 1041 (56.2) | 1490 (57.7) |
| Menstrual migraine | 103 (2.3) | 37 (2.0) | 66 (2.6) | 77 (1.7) | 33 (1.8) | 44 (1.7) |
| Status migrainosus | 1103 (24.9) | 442 (23.9) | 661 (25.6) | 806 (18.2) | 296 (16.0) | 510 (19.7) |