TABLE 3.
Specificity of the C6 ELISAa
| Sample descriptionb | No. of samples | No. positive | No. negative | Specificity (%) |
|---|---|---|---|---|
| Relapsing fever | 9 | 0 | 9 | 100 |
| Syphilis (UCLA) | 12 | 0 | 12 | 100 |
| Syphilis (NIH) | 10 | 0 | 10 | 100 |
| MS | 10 | 0 | 10 | 100 |
| ACA | 10 | 0 | 10 | 100 |
| RF | 10 | 0 | 10 | 100 |
| ANA | 10 | 0 | 10 | 100 |
| GBS | 1 | 0 | 1 | 100 |
| Myco | 5 | 0 | 5 | 100 |
| Hospital patients | 99 | 2 | 97 | 98 |
| Total | 176 | 2 | 174 | 99 |
a
The cutoff OD value (0.500) was defined as the mean plus 3 SDs for 97 serum samples obtained from hospitalized patients in an area where Lyme disease is not endemic. C6 ELISA was performed as described in Materials and Methods.
b
MS, multiple sclerosis; ACA, positive anticardiolipin antibody; RF, positive rheumatoid factor; ANA, positive antinuclear antibody; GBS, Guillain-Barré syndrome; Myco, mycobacterial infection.