Table 2.
Summary of the total PRO scores and number of patients by domain for the part 2 population (N = 2419)
| Assessment tool | n or n (%) | Mean (95% CI) score |
|---|---|---|
| EQ-5D-5L utility index score | 2415 | 0.76 (0.75 to 0.77) |
| EQ-5D-5L VAS score | 2419 | 67.3 (66.5 to 68.1) |
| EQ-5D-5L mobility* | ||
| I have no problems in walking about | 1928 (79.7) | (78.10 to 81.31) |
| I have slight problems in walking about | 311 (12.9) | (11.52 to 14.19) |
| I have moderate problems in walking about | 132 (5.5) | (4.55 to 6.36) |
| I have severe problems in walking about | 40 (1.7) | (1.15 to 2.16) |
| I am unable to walk about | 6 (0.2) | (0.05 to 0.45) |
| Missing | 2 (0.1) | (0.00 to 0.20) |
| EQ-5D-5L self-care* | ||
| I have no problems washing or dressing myself | 2206 (91.2) | (90.07 to 92.32) |
| I have slight problems washing or dressing myself | 143 (5.9) | (4.97 to 6.85) |
| I have moderate problems washing or dressing myself | 51 (2.1) | (1.54 to 2.68) |
| I have severe problems washing or dressing myself | 14 (0.6) | (0.28 to 0.88) |
| I am unable to wash or dress myself | 3 (0.1) | (0.00 to 0.26) |
| Missing | 2 (0.1) | (0.00 to 0.20) |
| EQ-5D-5L usual activities* | ||
| I have no problems doing my usual activities | 1229 (50.8) | (48.81 to 52.80) |
| I have slight problems doing my usual activities | 546 (22.6) | (20.91 to 24.24) |
| I have moderate problems doing my usual activities | 428 (17.7) | (16.17 to 19.21) |
| I have severe problems doing my usual activities | 175 (7.2) | (6.20 to 8.27) |
| I am unable to do my usual activities | 39 (1.6) | (1.11 to 2.11) |
| Missing | 2 (0.1) | (0.00 to 0.20) |
| EQ-5D-5L pain/discomfort* | ||
| I have no pain or discomfort | 541 (22.4) | (20.70 to 24.03) |
| I have slight pain or discomfort | 635 (26.3) | (24.50 to 28.00) |
| I have moderate pain or discomfort | 670 (27.7) | (25.91 to 29.48) |
| I have severe pain or discomfort | 470 (19.4) | (17.85 to 21.01) |
| I have extreme pain or discomfort | 99 (4.1) | (3.30 to 4.88) |
| Missing | 4 (0.2) | (0.00 to 0.33) |
| EQ-5D-5L anxiety/depression* | ||
| I am not anxious or depressed | 1063 (43.9) | (41.97 to 45.92) |
| I am slightly anxious or depressed | 722 (29.8) | (28.02 to 31.67) |
| I am moderately anxious or depressed | 437 (18.1) | (16.53 to 19.60) |
| I am severely anxious or depressed | 150 (6.2) | (5.24 to 7.16) |
| I am extremely anxious or depressed | 44 (1.8) | (1.29 to 2.35) |
| Missing | 3 (0.1) | (0.00 to 0.26) |
| HIT-6 total score | 2415 | 65.2 (65.0 to 65.5) |
| HIT-6 total score grade* | ||
| Little or no impact | 29 (1.2) | (0.77 to 1.63) |
| Some impact | 100 (4.1) | (3.34 to 4.93) |
| Substantial impact | 157 (6.5) | (5.51 to 7.47) |
| Severe impact | 2129 (88.0) | (86.72 to 89.31) |
| Missing | 4 (0.2) | (0.00 to 0.33) |
| mMIDAS total score | 2380 | 25.1 (24.4 to 25.9) |
| Modified MIDAS disability grade* | ||
| I | 160 (6.6) | (5.62 to 7.60) |
| II | 76 (3.1) | (2.45 to 3.84) |
| III | 162 (6.7) | (5.70 to 7.69) |
| IV | 1982 (81.9) | (80.40 to 83.47) |
| Missing | 39 (1.6) | (1.11 to 2.11) |
| MSQ-RFR score | 2417 | 43.8 (43.0 to 44.6) |
| MSQ-RFP score | 2415 | 59.2 (58.2 to 60.1) |
| MSQ-EF score | 2416 | 50.5 (49.4 to 51.6) |
| WPAI percentage work time missed | 1587 | 15.6 (14.3 to 16.9) |
| WPAI percentage impairment while working | 1512 | 48.6 (47.2 to 49.9) |
| WPAI percentage overall work impairment | 1496 | 52.6 (51.2 to 54.0) |
| WPAI percentage activity impairment | 2410 | 56.4 (55.3 to 57.4) |
| HADS overall score | 2395 | 14.6 (14.3 to 15.0) |
| HADS anxiety | 2401 | 8.0 (7.8 to 8.2) |
| HADS depression | 2401 | 6.7 (6.5 to 6.8) |
| HADS anxiety subscale—categorical* | ||
| Below 11 | 1700 (70.3) | (68.46 to 72.10) |
| 11 or above | 701 (29.0) | (27.17 to 30.79) |
| Missing | 18 (0.7) | (0.40 to 1.09) |
| HADS depression subscale—categorical* | ||
| Below 11 | 1923 (79.5) | (77.89 to 81.10) |
| 11 or above | 478 (19.8) | (18.17 to 21.35) |
| Missing | 18 (0.7) | (0.40 to 1.09) |
*Only 95% CI is reported. CIs were calculated using Wald formula/method
CI confidence interval, EF emotional function, EQ-5D-5L EuroQoL 5 dimensions, 5 levels, HADS Hospital Anxiety and Depression, HIT-6 headache impact test, mMIDAS modified Migraine Disability Assessment, MSQ migraine-specific quality of life, N number of patients included to analyze the respective questionnaire, PRO patient-reported outcome, RFP role function-preventive, RFR role function-restrictive, VAS visual analog scale, WPAI work productivity and activity impairment